DisneyQuest is wheelchair accessible, there are elevators to each floor.. Depending on the nature of disability some people might find some of the rides unsuitable.

EXPLORE ZONE

Virtual Jungle Cruise - transfer from wheelchair

Treasure of the Incas - stay in wheelchair

Hercules in the Underworld - stay in wheelchair

Aladdin's Magic Carpet ride - transfer from wheelchair

SCORE ZONE

Invasion! An Extraterrorestrial Alien Encounter - transfer from wheelchair

Mighty Ducks Pinball Slam - stay in wheelchair

Ride the Comix - transfer from wheelchair

The Underground & Sports Arena Arcades - stay in wheelchair

REPLAY ZONE

Buzz Lightyear's AstroBlaster - transfer from wheelchair

The Midway on the Moon - stay in wheelchair

CREATE ZONE

CyberSpace Mountain - transfer from wheelchair

Animation Academy - stay in wheelchair

Sid's Create-A-Toy - stay in wheelchair

Magic Mirror - stay in wheelchair

Living Easels - stay in wheelchair